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Published on: February 7, 2014
The Association of Radial Artery Pulse Wave Variables with the Pulse Wave Velocity and Echocardiographic Parameters
Li-Jie Qiao1, Zhen Qi1, Li-Ping Tu1
1Basic Medical College, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Insights
Traditional Chinese Medicine (TCM) pulse analysis reveals associations between radial artery pulse wave variables and cardiovascular changes in hypertension. These findings support TCM pulse diagnosis for assessing arterial stiffness and heart conditions.
Area of Science:
- Cardiovascular Physiology
- Traditional Chinese Medicine (TCM)
- Biomedical Engineering
Background:
- TCM pulse diagnosis is a traditional method for assessing health.
- Hypertension leads to arterial stiffness and cardiac target-organ damage.
- Understanding the pathophysiological mechanisms linking TCM pulse to cardiovascular changes is crucial.
Purpose of the Study:
- To explore the cardiovascular pathophysiological mechanisms of TCM pulse.
- To detect correlations between radial artery pulse wave variables and pulse wave velocity/echocardiographic parameters.
- To investigate these associations in healthy individuals, hypertensive patients, and those with hypertensive heart disease.
Main Methods:
- Recruited 200 Chinese subjects across three groups: healthy control, hypertension, and hypertensive heart disease.
- Collected TCM pulse images (Guan position, left hand), pulse wave velocity, and echocardiographic data.
- Utilized linear and stepwise regression analysis to assess associations, adjusting for confounding factors.
Main Results:
- Decreased t1, t5 and increased h1, h3/h1 pulse wave variables correlated with arterial stiffness in the total population.
- Decreased t3 and h5 correlated with arterial stiffness within specific groups.
- The dicrotic wave height (h5) was the most relevant variable, showing associations with interventricular septal thickness, posterior wall thickness, ejection fraction, and ventricular diameters.
Conclusions:
- Radial artery pulse wave variables are associated with arterial stiffness and echocardiographic changes in hypertension.
- These findings provide an experimental basis for understanding the cardiovascular pathophysiological mechanisms of TCM pulse variables.
- TCM pulse analysis offers a potential non-invasive method for cardiovascular risk assessment.
Abstract:
This study aims at exploring the cardiovascular pathophysiological mechanism of TCM (traditional Chinese medicine) pulse by detecting the correlation between radial artery pulse wave variables and pulse wave velocity/echocardiographic parameters. Two hundred Chinese subjects were enrolled in this study, which were grouped into health control group, hypertension group, and hypertensive heart disease group. Physical data obtained in this study contained TCM pulse images at "Guan" position of the left hand, pulse wave velocity, and echocardiographic parameters. Linear and stepwise regression analysis was performed to assess the association of radial artery pulse wave variables with pulse wave velocity and echocardiographic parameters in the total population and in each different group. After adjusting for related confounding factors, decrease of t1, t5 and increase of h1, h3/h1 were statistically associated with arterial stiffness in the total population (P<0.05). Moreover, the correlation study in each group showed that the decrease of both t3 and h5 was also related to arterial stiffness (P<0.05). In terms of echocardiographic parameters, the height of dicrotic wave indicated by h5 was the most relevant pulse wave variable. For the health control, h5 was negatively associated with interventricular septal thickness (VST) and left ventricular posterior wall thickness (PWT) (P<0.05), while for the hypertension population and those with target-organ damage to heart, increase of h5 might be associated with decrease of ejection fraction (EF) and increase of all the remaining echocardiographic parameters especially for left ventricular end-systolic diameter (LVDs) and Left ventricular end-diastolic diameter (LVDd) (P<0.05). In conclusion, we found radial artery pulse wave variables were in association with the arterial stiffness and echocardiographic changes in hypertension, which would provide an experimental basis for cardiovascular pathophysiological mechanism of radial artery pulse wave variables.
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