The Association of Radial Artery Pulse Wave Variables with the Pulse Wave Velocity and Echocardiographic Parameters

Li-Jie Qiao1, Zhen Qi1, Li-Ping Tu1

  • 1Basic Medical College, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

Insights

Traditional Chinese Medicine (TCM) pulse analysis reveals associations between radial artery pulse wave variables and cardiovascular changes in hypertension. These findings support TCM pulse diagnosis for assessing arterial stiffness and heart conditions.

Area of Science:

  • Cardiovascular Physiology
  • Traditional Chinese Medicine (TCM)
  • Biomedical Engineering

Background:

  • TCM pulse diagnosis is a traditional method for assessing health.
  • Hypertension leads to arterial stiffness and cardiac target-organ damage.
  • Understanding the pathophysiological mechanisms linking TCM pulse to cardiovascular changes is crucial.

Purpose of the Study:

  • To explore the cardiovascular pathophysiological mechanisms of TCM pulse.
  • To detect correlations between radial artery pulse wave variables and pulse wave velocity/echocardiographic parameters.
  • To investigate these associations in healthy individuals, hypertensive patients, and those with hypertensive heart disease.

Main Methods:

  • Recruited 200 Chinese subjects across three groups: healthy control, hypertension, and hypertensive heart disease.
  • Collected TCM pulse images (Guan position, left hand), pulse wave velocity, and echocardiographic data.
  • Utilized linear and stepwise regression analysis to assess associations, adjusting for confounding factors.

Main Results:

  • Decreased t1, t5 and increased h1, h3/h1 pulse wave variables correlated with arterial stiffness in the total population.
  • Decreased t3 and h5 correlated with arterial stiffness within specific groups.
  • The dicrotic wave height (h5) was the most relevant variable, showing associations with interventricular septal thickness, posterior wall thickness, ejection fraction, and ventricular diameters.

Conclusions:

  • Radial artery pulse wave variables are associated with arterial stiffness and echocardiographic changes in hypertension.
  • These findings provide an experimental basis for understanding the cardiovascular pathophysiological mechanisms of TCM pulse variables.
  • TCM pulse analysis offers a potential non-invasive method for cardiovascular risk assessment.

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