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A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
Published on: July 25, 2017
Oxidative Stress and the Microbiota-Gut-Brain Axis
Laura Dumitrescu1,2, Iulia Popescu-Olaru1,2, Liviu Cozma1,2
1Department of Clinical Neurosciences, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Str., 020021 Bucharest, Romania.
Abstract:
The gut-brain axis is increasingly recognized as an important pathway of communication and of physiological regulation, and gut microbiota seems to play a significant role in this mutual relationship. Oxidative stress is one of the most important pathogenic mechanisms for both neurodegenerative diseases, such as Alzheimer's or Parkinson's, and acute conditions, such as stroke or traumatic brain injury. A peculiar microbiota type might increase brain inflammation and reactive oxygen species levels and might favor abnormal aggregation of proteins. Reversely, brain lesions of various etiologies result in alteration of gut properties and microbiota. These recent hypotheses could open a door for new therapeutic approaches in various neurological diseases.
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