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Hypoprothrombinemia due to cefamandole
V M Conraads1, H E Demey, L G Heytens
1Department of Intensive Care, University of Antwerp, University Hospital, Belgium.
Klinische Wochenschrift
|December 1, 1988
Summary
Cefamandole, a cephalosporin antibiotic, can cause severe bleeding due to coagulation disturbances. This risk is linked to its N-methylthiotetrazole side chain, similar to moxalactam, and necessitates understanding its prevention and treatment.
Area of Science:
- Pharmacology
- Hematology
- Infectious Diseases
Background:
- Cephalosporin antibiotics are widely used for bacterial infections.
- Some cephalosporins possess side chains that may influence hemostasis.
- N-methylthiotetrazole is a chemical moiety found in certain cephalosporins.
Observation:
- Two patients developed severe coagulation disturbances.
- Extensive skin bleeding (ecchymosis) was observed in one patient.
- These events occurred secondary to cefamandole administration.
Findings:
- Cefamandole, like moxalactam, contains the N-methylthiotetrazole side chain.
- This side chain is implicated in the pathogenesis of hypoprothrombinemia.
- Hypoprothrombinemia is a condition of reduced prothrombin levels, affecting blood clotting.
Implications:
- Clinicians should be aware of the bleeding risk associated with cefamandole.
- Understanding the pathogenetic mechanisms is crucial for prevention and management.
- Monitoring coagulation parameters in patients receiving cefamandole may be warranted.