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Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease

Jing-Lu Jin1, Ye-Xuan Cao1, Li-Guo Wu2

  • 1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.

Journal of Thoracic Disease
|January 10, 2019
PubMed

Insights

The triglyceride glucose (TyG) index may predict cardiovascular events (CVEs) in patients with stable coronary artery disease (CAD). Higher TyG index levels are linked to increased CVE risk, suggesting its utility as a prognostic marker.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Biomarkers

Background:

  • The triglyceride glucose (TyG) index is an emerging marker for metabolic disorders.
  • Previous studies suggest an association between TyG index and cardiovascular disease (CVD) risk in healthy individuals.
  • The prognostic value of the TyG index in patients with stable coronary artery disease (CAD) remains undetermined.

Purpose of the Study:

  • To investigate the prognostic value of the triglyceride glucose (TyG) index in predicting future cardiovascular events (CVEs) in patients with stable coronary artery disease (CAD).

Main Methods:

  • A nested case-control study was conducted involving 3,745 patients with stable CAD.
  • Cardiovascular events (CVEs) included all-cause death, myocardial infarction, stroke, and revascularization.
  • The TyG index was calculated using fasting triglycerides and glucose levels; multivariable Cox models and Kaplan-Meier analysis were employed.

Main Results:

  • The TyG index was positively associated with an increased risk of CVEs (HR: 1.364).
  • Patients in the highest quartile of TyG index exhibited the lowest event-free survival.
  • A 1-SD increment in TyG index correlated with a 23.2% higher risk of CVEs, outperforming other related markers.

Conclusions:

  • The triglyceride glucose (TyG) index is positively associated with future cardiovascular events (CVEs) in patients with stable CAD.
  • The TyG index may serve as a valuable prognostic marker for predicting clinical outcomes in this patient population.
Abstract

Keywords:
Triglyceride glucose index (TyG index)outcomestable coronary artery disease

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