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Updated: Jan 31, 2026

A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Role of senescence induction in cancer treatment

Shenghui Qin1, Bradley A Schulte1, Gavin Y Wang1

  • 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, United States.

World Journal of Clinical Oncology
|January 10, 2019
PubMed

Insights

Cellular senescence, a permanent cell arrest, offers an alternative cancer treatment strategy. Inducing senescence in tumor cells shows promise against various cancers, especially when apoptosis pathways are compromised.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Therapeutics

Background:

  • Cellular senescence is a permanent cell cycle arrest mechanism.
  • Cancer cells often evade apoptosis, necessitating alternative therapeutic strategies.
  • Therapy-induced senescence is an emerging approach in cancer treatment.

Purpose of the Study:

  • To review recent advances in therapy-induced senescence for cancer treatment.
  • To discuss the clinical relevance of senescence induction in oncology.

Main Methods:

  • Literature review of studies on therapy-induced senescence.
  • Analysis of anticancer modalities that induce senescence.
  • Evaluation of clinical data on senescence-based therapies.

Main Results:

  • Senescence induction is a common response to various anticancer treatments.
  • Targeted therapeutics (e.g., CDK4/6 inhibitors) and immunotherapy can trigger senescence.
  • Senescence offers an apoptosis-independent mechanism for tumor suppression.

Conclusions:

  • Therapy-induced senescence is a clinically relevant strategy for cancer treatment.
  • This approach holds promise for overcoming therapeutic resistance.
  • Further research is needed to optimize senescence-based cancer therapies.
Keywords:
Aurora kinase inhibitorCancer treatmentCellular senescenceChemotherapyCyclin-dependent kinases 4/6 inhibitorImmunotherapyIonizing radiationT helper-1 cellsT helper-1 cytokines

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