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Updated: Jan 31, 2026

Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice
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Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

Martin Mackasey1,2, Emmanuel E Egom2, Hailey J Jansen1,2

  • 1Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

JACC. Basic to Translational Science
|January 10, 2019
PubMed

Keywords:
AP, action potentialAng II, angiotensin IICV, conduction velocityDD, diastolic depolarizationGmax, maximum conductanceHR, heart rateICa,L, L-type calcium currentICa,T, T-type calcium currentINCX, sodium–calcium exchanger currentIV, current voltage relationshipIf, hyperpolarization-activated currentNP, natriuretic peptideNPR, natriuretic peptide receptorNPR-C, natriuretic peptide receptor CSAN, sinoatrial nodeSBP, systolic blood pressureV1/2(act), voltage for 50% channel activationcSNRT, corrected sinoatrial node recovery timefibrosishypertensionion currentsnatriuretic peptidesinoatrial node

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