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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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Role of Endothelium in Doxorubicin-Induced Cardiomyopathy

Albert Z Luu1,2, Biswajit Chowdhury1, Mohammed Al-Omran2,3,4,5

  • 1Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.

JACC. Basic to Translational Science
|January 10, 2019
PubMed

Keywords:
AKT, protein kinase BBcl-2, B-cell lymphoma-2DNA, deoxyribonucleic acidERK1/2, extracellular signal-regulated kinase 1/2ET, endothelinLV, left ventricularMRP, multidrug resistance proteinNADPH, nicotinamide adenine dinucleotide phosphateNO, nitric oxideNOS, nitric oxide synthaseNRG-1, neuregulin-1PGI2, prostaglandin I2PI3K, phosphoinositide 3-kinaseRNS, reactive nitrogen speciesROS, reactive oxygen speciesZO, zona occludenscardiomyopathydoxorubicinendotheliumheart failure

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