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Collection of Post-mating Semen from the Female Reproductive Tract and Measurement of Semen Liquefaction in Mice
Published on: November 18, 2017
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Effect of ibuprofen on semen quality
1Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Andrologia
|January 10, 2019
Summary
Ibuprofen may negatively impact sperm parameters like motility and viability, potentially affecting fertility. However, conclusive evidence in humans is still needed, requiring further clinical research.
Area of Science:
- Reproductive biology
- Pharmacology
Background:
- Ibuprofen is a common nonsteroidal anti-inflammatory drug (NSAID).
- Its effects on semen quality and male fertility require comprehensive understanding.
Purpose of the Study:
- To systematically review and analyze the impact of ibuprofen on semen quality and fertilizing capability.
- To synthesize findings from in vitro and in vivo studies.
Main Methods:
- Systematic literature search of Scopus and PubMed databases (1986-2018).
- Keywords: "ibuprofen", "semen", "sperm".
- Inclusion of relevant published articles and abstracts.
Main Results:
- Most studies indicate adverse effects of ibuprofen on sperm motility, viability, count, and DNA integrity.
- These findings are primarily from in vitro and animal studies.
- Evidence for similar effects in humans remains inconclusive.
Conclusions:
- Ibuprofen may adversely affect sperm parameters through mechanisms like reduced testosterone and prostaglandin synthesis.
- Further clinical studies are crucial to confirm the impact of ibuprofen on human semen quality and fertility.
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