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SNHG15 functions as a tumor suppressor in thyroid cancer

Yongcun Liu1, Junli Li2, Feng Li3

  • 1Department of Oncology, The First People's Hospital of Xianyang, Xianyang, Shaanxi, China.

Journal of Cellular Biochemistry
|January 10, 2019
PubMed

Insights

Small nucleolar RNA host gene 15 (SNHG15) is downregulated in thyroid cancer, contrary to its role in other cancers. This long noncoding RNA (lncRNA) suppresses tumor growth, migration, and invasion, indicating a tumor-suppressive function.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Small nucleolar RNA host gene 15 (SNHG15) is implicated as an oncogenic long noncoding RNA (lncRNA) in several human cancers.
  • The expression and role of SNHG15 in thyroid cancer remain largely uncharacterized.

Purpose of the Study:

  • To investigate the expression status and clinical significance of SNHG15 in thyroid cancer.
  • To explore the functional impact of SNHG15 on thyroid cancer cell behaviors, including proliferation, migration, and invasion.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) was used to assess SNHG15 expression levels in thyroid cancer tissues and cell lines.
  • Correlation analysis was performed to link SNHG15 expression with various clinicopathological parameters and patient survival.
  • In vitro assays were conducted to evaluate the effects of SNHG15 overexpression on thyroid cancer cell proliferation, migration, and invasion.

Main Results:

  • SNHG15 expression was found to be significantly downregulated in thyroid cancer tissues and cells compared to normal controls.
  • Downregulation of SNHG15 correlated with advanced age, specific pathological classifications, clinical stage, larger tumor size, distant metastasis, and poorer disease-free survival.
  • Overexpression of SNHG15 in vitro led to the suppression of thyroid cancer cell proliferation, migration, and invasion.

Conclusions:

  • SNHG15 functions as a tumor suppressor in thyroid cancer, with its downregulation associated with adverse clinicopathological features and outcomes.
  • SNHG15 may serve as a potential diagnostic biomarker and therapeutic target for thyroid cancer.
Keywords:
SNHG15biomarkerlncRNAthyroid cancer

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