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Management of advanced prostate cancer: A systematic review of existing guidelines and recommendations

Athanasios Dellis1, Flora Zagouri2, Michalis Liontos2

  • 12nd Department of Surgery, National and Kapodistrian University of Athens, School of Medicine, Aretaieion Hospital, Athens, Greece; 1st Department of Urology, National and Kapodistrian University of Athens, School of Medicine, Laiko Hospital, Athens, Greece.

Cancer Treatment Reviews
|January 10, 2019
PubMed

Insights

Optimal treatment for advanced prostate cancer is evolving. This review analyzes current guidelines and trials to clarify sequencing and timing of therapies for better patient outcomes.

Area of Science:

  • Oncology
  • Urology
  • Medical Science

Background:

  • The treatment landscape for advanced prostate cancer is rapidly evolving with new therapies and molecular insights.
  • Optimal sequencing and early implementation of treatments remain debated due to limited high-quality evidence.

Purpose of the Study:

  • To systematically review existing guidelines and recent randomized trials for advanced prostate cancer.
  • To provide a comprehensive analysis of treatment options across different stages of advanced prostate cancer.
  • To detail available supportive care measures for patients with advanced prostate cancer.

Main Methods:

  • Systematic review of published clinical practice guidelines.
  • Inclusion of recent randomized controlled trials not covered in existing guidelines.
  • Comprehensive analysis of treatment efficacy and sequencing strategies.

Main Results:

  • Identification of key treatment modalities for various stages of advanced prostate cancer.
  • Evaluation of evidence supporting different therapeutic sequences.
  • Summary of supportive care interventions.

Conclusions:

  • Evidence-based recommendations for advanced prostate cancer treatment sequencing are needed.
  • Further research is crucial to optimize therapeutic strategies and improve patient management.
  • Personalized treatment approaches considering molecular characteristics are essential.
Keywords:
GuidelinesProstate cancer

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