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Pediatric heart transplantation from an influenza B-positive donor

Clyde J Smith1, Michael A McCulloch2, Debbie-Ann Shirley3

  • 1Division of Critical Care Medicine, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia.

Pediatric Transplantation
|January 10, 2019
PubMed

Insights

Expanding organ donor criteria is crucial for meeting rising heart transplant demand. A pediatric heart transplant was successfully performed using an organ from an influenza-positive donor, suggesting a broader donor pool is possible.

Area of Science:

  • Medicine
  • Transplant Surgery
  • Infectious Diseases

Background:

  • Increasing demand for heart transplantation necessitates expanding donor acceptance criteria.
  • Critically ill and highly sensitized patients present unique challenges in transplantation.
  • The donor pool growth has not kept pace with the rising demand for heart transplants.

Observation:

  • A pediatric heart transplant was performed using an organ from a donor infected with influenza virus.
  • The donor organ was initially refused by 197 potential recipients due to the influenza infection.
  • A literature review of solid organ transplants from influenza-positive donors was conducted.

Findings:

  • Transplantation of organs from donors with treatable infections, such as influenza, is feasible.
  • Including donors with influenza can potentially expand the donor pool for heart transplantation.
  • Successful pediatric heart transplant outcomes are achievable with organs from donors with influenza.

Implications:

  • Donor acceptance criteria can be expanded to include individuals with treatable infections.
  • This approach may increase organ availability for heart transplantation, benefiting more patients.
  • Further research into transplanting organs from donors with other treatable infections is warranted.

Keywords:
heart transplantinfluenzaoseltamivirpediatric

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