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Updated: Jan 31, 2026

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Published on: February 18, 2015
Initial platelet-to-lymphocyte count as prognostic factor in limited-stage small cell lung cancer
Qing Zhang1, Yanli Qu1, Hangyu Liu1
1Radiation Oncology Department of Thoracic Cancer, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Liaoning, Shenyang 110042, PR China.
Aim:
To assessed the prognostic significance of pretreatment platelet-to-lymphocyte ratio (PLR) in patients with limited-stage small cell lung cancer (LS-SCLC).
Methods:
We retrospectively analyzed 286 patients with LS-SCLC.
Results:
Sixty received chemotherapy alone, 158 sequential chemo- and radiotherapy, 38 concurrent chemo- and radiotherapy and 30 surgery combined with therapy. The cut-off value of pretreatment PLR was 152.1. The median progression free survival (PFS) and overall survival (OS) in the low and high PLR groups were 27.4 versus 19.5 (p = 0.002) and 14.9 versus 11.4 (p = 0.003) months. Multivariate analysis confirmed that PLR was an independent prognostic factor of OS (hazard ratio = 1.326; p = 0.040) and PFS (hazard ratio = 1.306; p = 0.044), respectively.
Conclusion:
Pretreatment PLR is an independent prognostic factor of OS and PFS in patients with LS-SCLC.
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