Related Experiment Video
Updated: Jan 31, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Monoclonal gammopathy of undetermined significance: A primary care guide
Jack Khouri1, Christy Samaras2,3, Jason Valent2,3
1Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA. khourij@ccf.org.
Abstract:
Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up. Patients with MGUS can be risk-stratified on the basis of the amount and type of their monoclonal protein as well as whether they have an abnormal light-chain ratio. Here, we provide a guide to the diagnosis, workup, and management of MGUS.
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