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Related Experiment Video

Updated: Jan 31, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Posttransplant maintenance therapy for acute leukemias.

Shyam K Poudel¹, Marcos de Lima, Leland Metheny

¹Stem Cell Transplant Program, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Current Opinion in Hematology

|January 10, 2019

Summary

Maintenance therapy after allogeneic stem cell transplant may reduce leukemia recurrence. Ongoing trials investigate epigenetic modifiers, tyrosine kinase inhibitors, and antibody-drug conjugates for preventing relapse in hematological malignancies.

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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Area of Science:

Hematology and Oncology
Transplantation Immunology

Background:

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological malignancies.
Leukemia recurrence remains the primary cause of HSCT failure, influenced by minimal residual disease and prognostic factors.

Purpose of the Study:

To review current research on maintenance therapy strategies aimed at preventing acute leukemia recurrence post-allogeneic HSCT.
To explore novel therapeutic agents and approaches for reducing post-transplant leukemia relapse.

Main Methods:

Review of current scientific literature and clinical trial data on post-HSCT maintenance therapies for acute leukemias.
Analysis of emerging therapeutic classes including epigenetic modifiers, tyrosine kinase inhibitors, and antibody-drug conjugates.

Main Results:

Phase I/II clinical trial data for several novel maintenance therapies are maturing and show encouraging results.
Initiation of multicenter phase III randomized clinical trials signifies progress in validating these post-transplant strategies.

Conclusions:

No standard of care currently exists for post-HSCT maintenance in acute leukemias.
Further investigation into the efficacy and safety of maintenance therapies is crucial.
Targeted cellular therapies, such as chimeric antigen receptor T cells, represent a promising future direction beyond conventional chemo-immunotherapy.