Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Velocity and Acceleration in Steady and Unsteady Flow01:11

Velocity and Acceleration in Steady and Unsteady Flow

410
In fluid mechanics, velocity and acceleration are key concepts for analyzing particle motion in both steady and unsteady flow. Consider a fluid particle moving along a pathline, where its velocity depends on its position and time. The particle's acceleration is obtained by differentiating the velocity with respect to time.
The acceleration can be generalized to any point in the flow, and expressed as components along three perpendicular directions, representing changes in velocity over...
410
Accelerators01:17

Accelerators

287
Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
287
Classifying Matter by Composition03:35

Classifying Matter by Composition

90.3K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.3K
Seedless Vascular Plants03:24

Seedless Vascular Plants

66.8K
Seedless Vascular Plants Were the First Tall Plants on Earth
66.8K
Average Acceleration01:30

Average Acceleration

13.6K
The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
13.6K
Instantaneous Acceleration01:16

Instantaneous Acceleration

23.1K
Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
23.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-based survival disparities persist in liver transplantation: MELD 3.0 fails to improve survival for waitlisted women.

Frontiers in transplantation·2026
Same author

Validation of a Wearable Photoplethysmography-Based Sensor for Compensatory Reserve Measurement Monitoring in Simulated Human Hemorrhage.

Sensors (Basel, Switzerland)·2026
Same author

Recipient Social Determinants and Geographic Access in DCD Liver Transplantation: Early Lessons During the Perfusion era.

Transplantation·2026
Same author

Mortality and graft loss in face transplantation: lessons from two decades of experience.

Clinical transplantation and research·2026
Same author

Lymphatic Recovery and Clinical Implications in Hand Allotransplantation: Insights From Indocyanine Green Lymphangiography.

Cureus·2026
Same author

Nail abnormalities in upper extremity transplantation: Perspectives and insights from systemic diseases and organ transplantation.

World journal of transplantation·2026

Related Experiment Video

Updated: Jan 31, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
10:31

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

8.0K

A Flow Dynamic Rationale for Accelerated Vascularized Composite Allotransplant Rejection.

Nicholas L Robbins1, Matthew J Wordsworth1, Bijaya K Parida1

  • 1From the RESTOR Program, 59th Medical Wing, and the San Antonio Military Medical Center, Joint Base San Antonio; University of Texas Health at San Antonio; Baylor Scott & White Health; and the Wake Forest Institute for Regenerative Medicine.

Plastic and Reconstructive Surgery
|January 10, 2019
PubMed
Summary

Vascularized composite allotransplants using long donor arteries (over 25 cm) experienced accelerated failure due to chronic rejection. This study suggests ischemia and intimal hyperplasia disrupt the Windkessel effect, leading to transplant loss.

More Related Videos

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research
09:36

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

6.1K
Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

8.9K

Related Experiment Videos

Last Updated: Jan 31, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
10:31

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

8.0K
Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research
09:36

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

6.1K
Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

8.9K

Area of Science:

  • Vascular surgery
  • Transplant immunology
  • Histopathology

Background:

  • Six knee and one hand vascularized composite allotransplants (VCAs) utilized donor arteries 25-40 cm long.
  • All VCAs failed between 14-56 months, attributed to chronic rejection.
  • A hand transplant failure at 8 months showed arterial pedicle thickening, intimal hyperplasia, and near "no-flow phenomenon" without cutaneous rejection.

Purpose of the Study:

  • To investigate the cause of accelerated failure in VCAs using long donor arterial pedicles.
  • To analyze the role of T-cell-mediated rejection and ischemia in VCA graft survival.

Main Methods:

  • Retrospective analysis of seven published VCA cases using donor arteries >25 cm.
  • Data collected from transplant teams in Germany and Louisville, Kentucky.
  • Outcome measures included transplant survival time and histopathologic findings.

Main Results:

  • A 100% accelerated failure rate was observed in VCAs with donor arteries >25 cm.
  • Graft loss was linked to T-cell-mediated rejection and ischemia-induced arterial necrosis.
  • Histopathology revealed intimal hyperplasia and disruption of the Windkessel effect.

Conclusions:

  • Hypothesizes accelerated rejection due to ischemia from disrupted vasa vasorum and intimal hyperplasia.
  • Suggests intimal hyperplasia, exacerbated by ischemia, disrupts the Windkessel effect, causing expedited transplant failure.