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Updated: Jan 31, 2026

Dissection of Larval Zebrafish Gonadal Tissue
Published on: April 26, 2017
Early development of a gonadal tumor in a patient with mixed gonadal dysgenesis
Sarah Crestian Cunha1, Juliana Gabriel Ribeiro de Andrade2, Camila Matsunaga de Angelis3
1Divisão de Cirurgia Pediátrica, Departamento de Cirurgia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM-Unicamp), Campinas, SP, Brasil.
Abstract:
A gonadal tumor was diagnosed in the first months of life in a patient with genital ambiguity, a 45,X/46,XY karyotype, and mixed gonadal dysgenesis. Gonadal biopsies at the age of 3 months revealed dysgenetic testes and a gonadoblastoma on the right testis. Even though gonadal tumors are rare in childhood, this case indicates that prophylactic removal of dysgenetic gonads should be performed as early as possible, especially when the female sex is assigned to a patient with a Y-chromosome sequence.
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