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INVASIVE NON-TYPE B HAEMOPHILUS INFLUENZAE DISEASE: REPORT OF EIGHT CASES

Mariana Tresoldi das Neves Romaneli1, Antonia Teresinha Tresoldi1, Ricardo Mendes Pereira1

  • 1Universidade Estadual de Campinas, Campinas, SP, Brazil.

Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo
|January 10, 2019
PubMed
Abstract

Insights

Invasive non-type b Haemophilus influenzae infections in children increased, with no identified nosocomial spread. Further surveillance is needed to understand this rise in non-type b H. influenzae disease.

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Microbiology
  • Bacteriology

Background:

  • Invasive non-type b Haemophilus influenzae (Hib) disease is a significant concern in pediatric populations.
  • Understanding the epidemiology and characteristics of non-type b Hib is crucial for public health.
  • This study focuses on a cluster of cases in a specific pediatric setting.

Purpose of the Study:

  • To document and analyze eight cases of invasive non-type b Haemophilus influenzae disease in children.
  • To investigate the clinical presentations, antimicrobial susceptibility, and genotypic characteristics of these isolates.
  • To determine the potential for nosocomial transmission and identify factors contributing to the observed increase.

Main Methods:

  • Retrospective case series of eight pediatric patients with invasive non-type b H. influenzae disease.
  • Analysis of clinical data, including diagnoses (bacteremia, meningitis, pleural fluid infection) and comorbidities.
  • Laboratory testing included ampicillin sensitivity, beta-lactamase production, and molecular typing (Pulsed-Field Gel Electrophoresis) for genotyping.

Main Results:

  • Eight cases of invasive non-type b H. influenzae disease were identified in children.
  • Common presentations included bacteremia, meningitis, and pleural fluid infections.
  • All tested strains were ampicillin-sensitive and non-beta-lactamase-producing; genotyping revealed diverse non-type b serotypes (a, c, and non-capsular).
  • Molecular typing excluded nosocomial transmission due to distinct genotypes.

Conclusions:

  • A real increase in invasive non-type b H. influenzae infections was observed.
  • No evidence of nosocomial transmission was found, and the cause for the increase remains unexplained.
  • Enhanced surveillance is recommended for accurate diagnosis, monitoring, and understanding of non-type b H. influenzae disease spectrum.

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