Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial learning deficits in old rats: a model for memory decline in the aged.

M Gallagher1, M A Pelleymounter

  • 1Department of Psychology, University of North Carolina, Chapel Hill 27514.

Neurobiology of Aging
|September 1, 1988
PubMed
Summary

Aging impairs spatial learning in rodents, likely due to hippocampal dysfunction. This deficit offers a valuable model for understanding human age-related memory decline.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eye on AKI - Are shifting trends the cue for a platform clinical trial?

Journal of critical care·2026
Same author

CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity.

Heliyon·2023
Same author

Quantifying virtual self-motion sensations induced by galvanic vestibular stimulation.

Journal of vestibular research : equilibrium & orientation·2023
Same author

Visuo-vestibular conflicts within the roll plane modulate multisensory verticality perception.

Neuroscience letters·2022
Same author

Health Science Students as PPE Coaches in the Emergency Department - a Pandemic Pilot Project.

Infection prevention in practice·2021
Same author

Corrigendum to "Timing of continuous renal replacement therapy in severe acute kidney injury patients with fluid overload: A retrospective cohort study" [J Crit Care. 2021 Aug; 64: 226-236].

Journal of critical care·2021

Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Animal Models

Background:

  • Spatial learning is crucial for survival and navigation.
  • Aging is associated with cognitive decline, particularly in memory functions.
  • Rodent models are widely used to study age-related cognitive changes.

Purpose of the Study:

  • To review recent research on age-related spatial learning impairments in rodents.
  • To explore the neurobiological mechanisms underlying these deficits.
  • To assess the utility of aged rodents as a model for human cognitive aging.

Main Methods:

  • Literature review of studies on spatial learning in aged rodents.
  • Analysis of neurobiological findings related to aging and spatial memory.
  • Synthesis of evidence linking hippocampal function to age-related deficits.

Related Experiment Videos

Main Results:

  • Aged rodents exhibit significant impairments in spatial learning tasks.
  • Hippocampal dysfunction is consistently implicated in these deficits.
  • These deficits correlate with the degree of normal aging.

Conclusions:

  • Age-related spatial learning deficits in rodents are primarily driven by hippocampal dysfunction.
  • Aged rodents serve as a relevant model for studying human age-related memory decline.
  • Understanding these mechanisms can inform strategies to mitigate cognitive aging.