The Pattern of Tpeak-Tend Interval and QTdis, and Pdis in Children with Brucellosis
Mecnun Çetin1, Nevzat Turfan2, Kamuran Karaman3
1Department of Pediatric Cardiology, Van Yuzuncu Yil Universitiy, Van, Turkey.
Insights
Brucellosis infection significantly impacts heart function, prolonging key electrocardiogram intervals related to arrhythmia and sudden cardiac death risk. This suggests more subclinical cardiac involvement in brucellosis than previously recognized.
Area of Science:
- Cardiology
- Infectious Diseases
- Electrophysiology
Background:
- Brucellosis is a zoonotic infection with potential systemic complications.
- Cardiac involvement in brucellosis, particularly subclinical forms, requires further investigation.
Purpose of the Study:
- To investigate the effects of brucellosis on the cardiac conducting system.
- To assess cardiac inflammation markers in brucellosis patients.
Main Methods:
- Electrocardiogram (ECG) parameters were recorded from 42 brucellosis patients and 39 healthy children.
- Pre- and post-treatment ECG data were analyzed for both groups.
Main Results:
- Key ECG indicators (Pmax, Pdis, QTmax, QTdis, QTcdis, Tp-edis, and related ratios) were significantly prolonged in brucellosis patients.
- These prolonged intervals are associated with increased risk of severe arrhythmias and sudden cardiac death.
Conclusions:
- Brucellosis causes significant cardiac involvement, often in a subclinical manner.
- Inflammation associated with brucellosis affects cardiac electrophysiology and conduction.
Objective:
To investigate the effect of inflammation on the conducting system of the heart in patients diagnosed with brucellosis.
Methods:
A total of 42 patients diagnosed with brucellosis and 39 age and sex-matched healthy children were enrolled into the study. Pre- and post-treatment electrocardiographic parameters in brucellosis and control group were recorded from an electrocardiogram for each patient.
Results:
The results indicated that the parameters including Pmax, Pdis, QTmax, QTdis, QTcdis, Tp-edis interval and Tp-emax/QTmax and Tp-emax/QTcmax ratios, which are known to be key indicators for the prediction of severe atrial or ventricular arrhythmia and sudden cardiac death and also important parameters used as the indicators for the non-invasive evaluation of the transmural heterogeneity were significantly longer in the study group compared with the control group (p < 0.05).
Conclusion:
In this study, it was determined that the brucella disease had more cardiac involvement than thought, and this was more in the subclinical form of cardiac involvement.
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