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Cold autoadsorption

Ernest M Ekema¹

¹Immunohematology Reference Laboratory, American Red Cross, Greater Chesapeake and Potomac Region.

Immunohematology

|January 10, 2019

Abstract

Conclusions:

Cold-reactive autoantibodies can mask the presence of underlying clinically significant alloantibodies in a patient's plasma or serum. These autoantibodies are problematic when performing laboratory procedures such as ABO typing, red blood cell (RBC) crossmatching, antibody detection testing, and antibody identification. To avert the masking of clinically significant alloantibodies in a patient's plasma or serum, adsorption studies can be performed at 4°C using autologous RBCs if the patient has not been recently transfused.

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Separation of multiple antibodies by adsorption with allogeneic red blood cells.

Immunohematology·2018

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