Area of Science:

• Cardiology
• Pharmacology

Background:

• Low adherence to drug therapy is a significant challenge for patients with ischemic heart disease (IHD).
• This issue persists even after invasive procedures like myocardial revascularization.
• Understanding adherence patterns is crucial for optimizing treatment outcomes.

Purpose of the Study:

• To identify which components of IHD drug therapy patients are least likely to continue taking.
• To explore optimal combination preparations with fixed doses of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors.
• To review the role of bisoprolol and perindopril in IHD management.

Main Methods:

• Literature analysis to identify adherence challenges.
• Review of existing data on drug combinations for IHD.
• Examination of specific agents like bisoprolol and perindopril.

Main Results:

• The study aims to pinpoint specific drug classes or components with lower adherence rates in IHD patients.
• Identifies the need for simplified treatment regimens through combination therapies.
• Highlights the potential of fixed-dose combinations for improving adherence.

Conclusions:

• Addressing adherence barriers is essential for effective IHD management.
• Fixed-dose combination preparations may improve patient compliance.
• Further research into optimal drug combinations is warranted for IHD patients.