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Updated: Jan 31, 2026

Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice
Published on: August 23, 2022
A decade of diverse microglial-neuronal physical interactions in the brain (2008-2018)
Joseph O Uweru1, Ukpong B Eyo1
1Department of Neuroscience, University of Virginia, Charlottesville, VA, United States; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, United States; Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA, United States.
Abstract:
Microglia are unique cells of the central nervous system (CNS) with a distinct ontogeny and molecular profile. They are the predominant immune resident cell in the CNS. Recent studies have revealed a diversity of transient and terminal physical interactions between microglia and neurons in the vertebrate brain. In this review, we follow the historical trail of the discovery of these interactions, summarize their notable features, provide implications of these discoveries to CNS function, emphasize emerging themes along the way and peak into the future of what outstanding questions remain to move the field forward.
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