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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Protective effect of inulin on methotrexate- induced liver toxicity in mice

Heibatullah Kalantari1, Nooshin Asadmasjedi2, Mohammad Reza Abyaz2

  • 1Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 11, 2019
PubMed

Insights

Inulin protects the liver from methotrexate-induced toxicity by modulating oxidative stress and apoptotic factors. This study highlights inulin

Area of Science:

  • Pharmacology and Toxicology
  • Hepatology
  • Biochemistry

Background:

  • Methotrexate (MTX) is a widely used drug for cancer and inflammatory conditions, but it can cause significant liver toxicity.
  • Inulin, a prebiotic fiber, possesses antioxidant properties and has demonstrated potential hepatoprotective effects.

Discussion:

  • This study investigated the efficacy of inulin in mitigating MTX-induced liver injury in a mouse model.
  • Inulin administration prior to MTX treatment was evaluated for its impact on liver function tests, oxidative stress biomarkers, and apoptotic factor expression.

Key Insights:

  • MTX administration led to substantial liver damage, evidenced by altered serum markers and histopathological changes.
  • Inulin pre-treatment significantly ameliorated MTX-induced liver injury, restoring normal liver function and reducing oxidative stress.
  • Inulin modulated the expression of apoptotic factors, including Bcl-2 and caspase-3, and microRNA-122 (miR-122) levels.

Outlook:

  • The findings suggest that inulin's hepatoprotective mechanisms involve the regulation of apoptosis and oxidative stress pathways.
  • Further research could explore optimal inulin dosages and its potential clinical application in preventing MTX-associated hepatotoxicity.
  • Inulin may represent a promising natural therapeutic agent for managing drug-induced liver injury.
Keywords:
HepatoprotectiveInulinMethotrexateMicemiR-122

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