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Updated: Jan 31, 2026

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer
Published on: October 1, 2016
Two highly selective and sensitive fluorescent imidazole derivatives design and application for 2,4,6-trinitrophenol
Hong-Lin Ding1, Li-Dong Chen1, Ning Wang1
1College of Chemistry and Chemical Engineering, Liaoning Normal University, Huanghe Road 850#, Dalian 116029, PR China.
Abstract:
In this paper, two nanoparticle fluorescence sensors L1 and L2 were designed and synthesized for the detection of 2,4,6-trinitrophenol (TNP) in water. Density functional theory (DFT) calculations were used to assist in designing sensors and explaining the detection mechanism. A further illustration of the fluorescence quenching mechanism was also studied by 1H NMR titration and UV-Vis absorption spectroscopy. The Job's plot demonstrates the combined stoichiometry of the sensor and TNP. Both sensors show low detection limit apparently (0.17 and 0.49 μM), fast and highly selective fluorescence response to TNP compared to other nitro-compounds. Moreover, L1 and L2 were successfully applied for the determination of TNP in real water samples.
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