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Updated: Jan 31, 2026

Author Spotlight: Enhancing Success of Ultrasound-Guided Neuraxial Anesthesia in Cases with Difficult Anatomy
Published on: January 31, 2025
Meningitis after a combined spinal epidural anesthesia: A case report
Dong Hee Woo1, Sang Ho Kim1, Sul Jang1
1Department of Anesthesiology and Pain Medicine, National Medical Center, Seoul, Korea.
Abstract:
The incidence of post-dural puncture meningitis is very low. A 44-year-old patient developed a fever (38degrees C, headache, neck stiffness, nausea, and vomiting after combined spinal epidural (CSE) anesthesia and surgery for closed reduction and internal fixation (CRIF) with intramedullary (IM) nailing, tibia, Rt. With a preliminary diagnosis of bacterial meningitis, empiric broad spectrum antimicrobial treatment was immediately started after cerebrospinal fluid (CSF) sampling. The CSF was clear and revealed a white blood cell count, protein, glucose, and pressure of 146/micrometer, 225 mg/dl, 48 mg/dl (serum 151 mg/dl), and 26 cmH2O, respectively. The CSF stain and culture were negative. Considering the injection of preventive antibiotics before CSE anesthesia, partially treated bacterial meningitis was suspected. Four weeks later, clinical symptoms had improved before the patient was discharged.
Insights
Post-dural puncture meningitis is rare. This case highlights a suspected partially treated bacterial meningitis following combined spinal epidural anesthesia, with symptoms improving after initial treatment.
Area of Science:
- Anesthesiology
- Infectious Diseases
- Neurosurgery
Background:
- Post-dural puncture meningitis is a rare but serious complication.
- Combined spinal epidural (CSE) anesthesia is frequently used for orthopedic procedures.
- Early diagnosis and treatment are crucial for favorable outcomes.
Purpose of the Study:
- To report a case of suspected partially treated bacterial meningitis after CSE anesthesia.
- To discuss the diagnostic challenges and management of this rare complication.
Main Methods:
- A case report of a 44-year-old patient who developed meningitis symptoms post-CSE anesthesia.
- Cerebrospinal fluid (CSF) analysis including cell count, protein, glucose, and culture.
- Empiric broad-spectrum antimicrobial treatment initiated.
- Clinical monitoring and outcome assessment.
Main Results:
- The patient presented with fever, headache, and neck stiffness post-CSE anesthesia and surgery.
- CSF analysis showed elevated white blood cells and protein, but negative Gram stain and culture.
- Partially treated bacterial meningitis was suspected due to pre-anesthesia antibiotics.
- Clinical symptoms improved with continued antimicrobial therapy.
Conclusions:
- While rare, bacterial meningitis should be considered in patients with suggestive symptoms after neuraxial anesthesia.
- Negative CSF cultures may occur in partially treated cases.
- Prompt empiric antibiotic treatment is essential for managing suspected meningitis.
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