Related Experiment Video
Updated: Jan 31, 2026

The Role of Indocyanine Green Fluorescence in Complex Laparoscopic Cholecystectomy Navigation
Published on: January 31, 2025
The effect of intraoperative remifentanil infusion on analgesic requirements after laparoscopic cholecystectomy
Jae Jun Lee1, Sung Jun Hong1, Joo Sung Kim1
1Department of Anesthesiology and Pain Medicine, Hallym University, College of Medicine, Chuncheon, Korea. h70sm@hallym.or.kr.
Background:
This study was designed to evaluate the effect of intraoperative remifentanil infusion on postoperative analgesics requirements after laparoscopic cholecystectomy.
Methods:
One hundred adult patients scheduled for elective laparoscopic cholecystectomy were enrolled. Patients were randomly allocated to 2 groups to receive sevoflurane with remifentanil infusion (Group R) or not (group C). Sevoflurane concentration and remifentanil dose were adjusted to maintain BIS 40-60 and blood pressure within 20% of the preoperative value, respectively. We assessed the pain intensity by using the four-point verbal rating scale (VRS) (0 = no pain. 1 = slight pain, 2 = moderate pain, 3 = intense or severe pain) at 15 min intervals for 1 hour in recovery room and then at 3-h intervals for 24 h in surgical ward. The analgesic medication was given when VRS score was > or =2 or patients requested it.
Results:
There were no differences between the two groups with respect to the requirements for postoperative analgesics in recovery room and surgical ward.
Conclusions:
Continuous remifentanil infusion (0.09 +/- 0.05 ug/kg/min) during laparoscopic cholecystectomy does not cause hyperalgesia and more analgesic requirements.
More Related Videos
Related Concept Videos
Requirements for Human Life
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Proteins: Dietary Sources and Requirements
Oxygen Requirements and Growth Patterns
Carbohydrates: Dietary Sources and Requirements

