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Extracellular Matrix in Development and Disease.

Julia Thom Oxford1,2,3,4, Jonathon C Reeck5,6, Makenna J Hardy7,8

  • 1Center of Biomedical Research Excellence in Matrix Biology, Boise State University, Boise, ID 83725-1511, USA. joxford@boisestate.edu.

International Journal of Molecular Sciences
|January 11, 2019
PubMed
Summary
This summary is machine-generated.

The extracellular matrix (ECM) is a key component in multicellular organisms, organizing cells and tissues. Its evolution was crucial for the development of complex animal life.

Keywords:
cancerextracellular matrixhereditary diseasesintegrinsmusclereproductiontissue engineering

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Area of Science:

  • Evolutionary biology
  • Cell biology
  • Biochemistry

Background:

  • The emergence of multicellularity in metazoan organisms involved the development of an extracellular matrix (ECM).
  • The ECM is a complex network of proteins and molecules situated outside of cells.
  • This matrix plays a critical role in cell adhesion, communication, and tissue structure.

Discussion:

  • The ECM's composition and organization are vital for maintaining tissue integrity and function.
  • Understanding ECM dynamics provides insights into developmental processes and disease mechanisms.
  • Variations in ECM components across species reflect evolutionary adaptations.

Key Insights:

  • The extracellular matrix (ECM) is a defining feature in the evolution of multicellular animals.
  • ECM facilitates spatial arrangement and organization of cells, leading to tissue formation.
  • This proteinaceous network is fundamental for metazoan complexity.

Outlook:

  • Further research into ECM's role in evolution can illuminate the origins of animal diversity.
  • Investigating ECM in different metazoan lineages may reveal novel therapeutic targets.
  • Advanced imaging and biochemical techniques will enhance our understanding of ECM structure-function relationships.