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Distribution of Bacillus Calmette-Guérin (BCG) Vaccine in Victoria 2013-2015
Nicole X Wong1,2, Nigel Crawford3,4,2, Jock Lawrie5
1Monash Children's Hospital, Melbourne. General Medicine, Royal Children's Hospital (RCH), Melbourne.
Insights
The Bacillus Calmette-Guérin (BCG) vaccine is crucial for preventing tuberculosis (TB) in high-risk children. Analysis revealed disparities in BCG vaccine distribution, particularly for infants of African background, indicating a need for improved awareness and equitable access.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- The Bacillus Calmette-Guérin (BCG) vaccine plays a vital role in mitigating tuberculosis (TB) disease among high-risk children.
- In Victoria, the Royal Children's Hospital (RCH) and Monash Health (MH) have been the primary providers of the BCG vaccine since 2013.
Purpose of the Study:
- To conduct a retrospective analysis of BCG vaccine distribution at RCH and MH.
- To compare BCG vaccine uptake across various demographic cohorts with local birth data.
- To identify potential inequities in BCG vaccine service delivery.
Main Methods:
- Retrospective analysis of patients receiving BCG vaccine at RCH and MH between November 1, 2013, and November 30, 2015.
- Comparison of patient data with Victorian birth data from 2012.
- Analysis of demographic factors including parental ethnicity and travel destinations.
Main Results:
- A total of 3,975 patients received the BCG vaccine; detailed data was available for 830 RCH patients.
- The majority of vaccinations (98.9%) were for children traveling to Asia.
- A significant disparity was observed in the uptake of the BCG vaccine among infants of African background compared to Victorian birth data, suggesting a need for improved awareness and equity.
Conclusions:
- The study highlights potential gaps in awareness and equity of BCG vaccine services.
- There is a particular need to improve access for infants of African background.
- Optimizing BCG vaccine delivery can enhance protection against TB in vulnerable populations.
Background:
The Bacillus Calmette-Guérin (BCG) vaccine has an important role mitigating tuberculosis (TB) disease in high risk children. In Victoria, immunisation services at the Royal Children's Hospital (RCH) and Monash Health (MH) have been funded as the major providers of BCG vaccine since 2013.
Methods:
In this article, we performed retrospective analysis of patients who attended RCH and MH for BCG between 1st November 2013- 30th November 2015. This was compared with local birth data in order to portray the distribution of BCG vaccine across various cohorts.
Outcomes:
A total of 3,975 patients received BCG vaccine (1,775 at Monash, 2,200 from RCH). Detailed data is only available on 830 RCH patients. The median age of the study population was 6.9 months (IQR 3.9-11.3). The majority of children (98.9%, 2,575/2,604) received BCG vaccine prior to overseas travel. Of these, 96.0% (2,474/2,575) were travelling to countries in Asia. Only 13/2,604 (0.5%) were given BCG vaccine prior to travel to a country with low incidence of TB. Most infants were of Asian descent (93.3% mothers [2,425/2,604], 90.4% [2,346/2,604] fathers). A much smaller proportion was African (1.4% mothers [35/2,604], 1.5% [39/2,604] fathers). This contrasts with 2012 Victorian birth data, which showed that 82.2% (7,508/ 9,134) babies born to mothers from high TB prevalence countries were of Asian descent, whereas 8.9% (816/ 9,134) were of African descent. These results highlight scope to improve awareness and equity of BCG vaccine service, particularly to infants of African background.
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