Cross-Domain and Viral Interactions in the Microbiome

Area of Science:

• Microbiology
• Human Health
• Ecology

Background:

• The human microbiome's significance for health is increasingly acknowledged.
• Research often emphasizes the bacterial component, particularly in the gut.
• The microbiome encompasses diverse life forms beyond bacteria.

Purpose of the Study:

• To review the major groups constituting the human microbiome.
• To explore inter-kingdom interactions within the microbiome.
• To discuss the host-microbiome relationship.

Main Methods:

• Literature review and synthesis of current research.
• Focus on interactions between different microbial groups (bacteria, archaea, fungi, viruses, helminths).
• Examination of how these interactions affect the multicellular host.

Main Results:

• The human microbiome comprises bacteria, archaea, fungi, helminths, and viruses.
• These diverse organisms interact within shared host niches.
• Interactions include competition, synergy, and antagonism, impacting host health.

Conclusions:

• A comprehensive understanding of the microbiome requires considering all its components.
• Interactions between different microbial groups are crucial for host well-being.
• Further research into these complex interactions is warranted.