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Updated: Jan 31, 2026

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE

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Published on: May 14, 2019

Electrically induced verbal perseveration: A striatal deafferentation model.

Emmanuel Mandonnet¹, Guillaume Herbet², Sylvie Moritz-Gasser²

¹From the Department of Neurosurgery (E.M., I.P., F.R.), Lariboisière Hospital; University Paris 7 (E.M.); Frontlab (E.M.), INSERM, Institut du Cerveau et de la Moelle, Paris, France; Sherbrook Connectivity Imaging Lab (F.R.), Department of Computer Science, Faculty of Sciences, Université de Sherbrook, Quebec, Canada; Department of Neurosurgery (G.H., S.M.-G., H.D.), Hôpital Gui de Chauliac, Montpellier Medical University Center; Institute of Neuroscience of Montpellier (G.H., S.M.-G., H.D.), INSERM U1051; and University of Montpellier (G.H., S.M.-G., H.D.), Montpellier, France. emmanuel.mandonnet@aphp.fr.

|January 11, 2019

Summary

This study mapped brain connections related to verbal perseveration (VP) during glioma surgery. Findings reveal specific white matter tracts involved in VP, supporting a deafferentation model of cognitive function.

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Area of Science:

Neuroscience
Cognitive Neurology
Neurosurgery

Background:

Verbal perseveration (VP) is a cognitive deficit impacting speech production.
The deafferentation cognitive model proposes VP arises from disrupted neural pathways.
Understanding the neural basis of VP is crucial for managing speech disorders post-neurosurgery.

Purpose of the Study:

To identify the neural correlates of verbal perseveration (VP) using connectomics.
To analyze the brain's white matter connectivity associated with VP during awake glioma surgery.
To elucidate the anatomical implementation of the deafferentation cognitive model for VP.

Main Methods:

Retrospective review of 21 patients undergoing awake left glioma surgery with VP.
Anatomical localization of VP-eliciting stimulation sites on postoperative MRI.
Connectomic analysis using Tractotron and disconnectome mapping of identified sites.

Main Results:

VP stimulation sites were found in white matter near the caudate nucleus, external capsule, and temporal horn.
Connectomic analysis identified involvement of the inferior fronto-occipital fasciculus, frontostriatal tract, and anterior thalamic radiations.
These tracts link the lexico-semantic system, striatum, and thalamus.

Conclusions:

The study proposes an anatomical framework for the deafferentation model of VP.
This model involves information flow between the lexico-semantic system, striatum, and thalamus.
The striato-thalamic system acts as a filter, modulating cognitive output and inhibiting competing responses.