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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
Published on: November 22, 2024
Challenges and strategies for developing efficacious and long-lasting malaria vaccines
James G Beeson1,2,3, Liriye Kurtovic4,2, Carlota Dobaño5
1Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia. beeson@burnet.edu.au michelle.boyle@qimrberghofer.edu.au.
Abstract:
Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.
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