The importance of insulin donations for children in 43 low- and middle-income countries

Hans V Hogerzeil1, Sterre Recourt2

  • 1Global Health Unit, Department of Health Sciences, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. hans.hogerzeil@kpnmail.nl.

Insights

Insulin access is critical for children with type 1 diabetes in low- and middle-income countries (LMIC). Sustainable national programs, not just donations, can improve survival and health outcomes for these young patients.

Area of Science:

  • Endocrinology
  • Global Health
  • Pediatric Diabetes Management

Background:

  • Diabetes mellitus is a growing global health concern, with millions requiring insulin.
  • Access to insulin is severely limited in low- and middle-income countries (LMIC), leading to premature deaths, particularly among children.
  • Type 1 diabetes affects a significant pediatric population globally.

Purpose of the Study:

  • To evaluate the impact of insulin donation programs on children with type 1 diabetes in LMIC.
  • To demonstrate the feasibility of diagnosing, treating, and preventing complications in this population.
  • To propose a sustainable model for national diabetes care and prevention programs.

Main Methods:

  • Analysis of experiences from insulin-producing companies' support programs in 43 LMIC since 2000.
  • Assessment of improvements in survival rates, body weight, glucose levels, and complication frequency.
  • Development of a ten-step transition process for sustainable national programs.

Main Results:

  • Insulin donation programs have shown significant improvements in survival, body weight, and glucose control.
  • Diagnosis, treatment, and prevention of fatal complications are achievable in LMIC settings.
  • Medicine donations alone are not a sustainable long-term solution.

Conclusions:

  • Effective type 1 diabetes care for children is possible in LMIC with dedicated programs.
  • A transition from donation-based aid to sustainable national healthcare systems is essential.
  • A proposed ten-step process offers a pathway to comprehensive and sustainable diabetes management.

Related Concept Videos

Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.9K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
3.1K
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
724
Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
1.3K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
293
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
762