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Gadolinium Deposition in the Brain: Current Updates.

Jin Woo Choi1, Won-Jin Moon1

  • 1Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

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|January 11, 2019
PubMed
Summary

Gadolinium-based contrast agents (GBCAs) can deposit in the brain, particularly linear types. This review summarizes GBCA brain deposition and its clinical significance.

Keywords:
Brain depositionChelating ligandDeposition mechanismGadoilniumMinistry of Food and Drug Safety in KoreaPharmacovigilance and Risk Assessment CommitteeThermodynamic stability

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Area of Science:

  • Radiology
  • Neurology
  • Pharmacology

Background:

  • Gadolinium-based contrast agents (GBCAs) are widely used in MRI.
  • Concerns exist regarding GBCA retention in the body, especially in patients with renal impairment.
  • Previous research linked GBCAs to nephrogenic systemic fibrosis.

Purpose of the Study:

  • To review current knowledge on Gadolinium-based contrast agent deposition in the brain.
  • To discuss the clinical implications of GBCA brain deposition.

Main Methods:

  • Literature review of studies investigating GBCA deposition in brain tissue.
  • Analysis of the relationship between GBCA chelate structure and brain deposition.
  • Synthesis of clinical data related to GBCA brain accumulation.

Main Results:

  • Accumulating evidence suggests GBCAs are not fully cleared and can deposit in human tissues, including the brain.
  • Linear GBCAs are predominantly associated with brain deposition in reported studies.
  • The specific chelate structure of GBCAs influences their propensity for brain deposition.

Conclusions:

  • Gadolinium-based contrast agents, particularly linear agents, can lead to deposition in the brain.
  • Understanding GBCA brain deposition is crucial for assessing long-term safety and clinical implications in neuroimaging.
  • Further research is needed to fully elucidate the mechanisms and consequences of GBCA brain retention.