Related Experiment Video
Updated: Jan 31, 2026
11:50
A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
Published on: February 4, 2022
4.6K
Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study
Dong-Yi Lan1, Pei-Wen Zhu1, Ying He1
1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, Jiangxi, China.
Translational Vision Science & Technology
|January 11, 2019
Summary
Acute eye pain (EP) patients show reduced gray matter volume (GMV) in key brain areas compared to healthy controls. This neuroimaging finding may help understand EP
Area of Science:
- Neuroimaging
- Neuroscience
- Medical Imaging
Background:
- Acute eye pain (EP) is a common clinical condition requiring better understanding of its underlying neurological mechanisms.
- Previous research has not fully elucidated the structural brain changes associated with acute EP.
Purpose of the Study:
- To compare gray matter volume (GMV) differences between acute eye pain (EP) patients and healthy controls (HCs) using voxel-based morphometry (VBM).
- To investigate the relationship between GMV alterations and clinical features or behavioral performance in EP patients.
Main Methods:
- Recruited 24 acute EP patients and 24 age-, sex-, and education-matched HCs.
- Acquired functional magnetic resonance imaging (fMRI) 3D T1-weighted brain images.
- Analyzed GMV using VBM and employed receiver operating characteristic (ROC) curve analysis for diagnostic distinction.
Main Results:
- Acute EP patients exhibited significantly lower GMV in the left cerebellum posterior lobe, left limbic lobe, right and left insula, left thalamus, left caudate, and right cuneus compared to HCs.
- A slight decrease in whole-brain white matter volume (WMV) was observed in acute EP patients.
Conclusions:
- Abnormal GMV reduction in specific brain regions suggests underlying neural mechanism alterations in acute EP.
- These findings may indicate functional disorders in somatosensory, motor, and cognitive functions associated with acute EP.
- VBM offers a potential diagnostic method for identifying the cause of acute EP and opens new avenues for research.
More Related Videos
Related Concept Videos
02:49Classifying Matter by State
103.2K
Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars.
103.2K
03:35Classifying Matter by Composition
90.3K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.3K
02:59The Atomic Theory of Matter
127.9K
The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...
127.9K
02:57Physical and Chemical Properties of Matter
166.3K
The characteristics that enable us to distinguish one substance from another are called properties.
166.3K
01:13What is Matter?
16.6K
The substance of the universe—from a grain of sand to a star—is called matter. Scientists define matter as anything that occupies space and has mass. An object’s mass and its weight are related concepts, but not quite the same. An object’s mass is the amount of matter contained in the object and is the same whether that object is on Earth or in the zero-gravity environment of outer space. An object’s weight, on the other hand, is its mass as affected by the pull of...
16.6K
01:20States of Matter
2.9K
Solids, liquids, and gases are the three states of matter commonly found on Earth. A solid is rigid and possesses a definite shape. A liquid flows and takes the shape of its container, except it forms a flat or slightly curved upper surface when acted upon by gravity. Both liquid and solid samples have volumes nearly independent of pressure. A gas takes both the shape and volume of its container.
Scientists have discovered a fourth state of matter, plasma, that occurs naturally in the interiors...
Scientists have discovered a fourth state of matter, plasma, that occurs naturally in the interiors...
2.9K