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Nephrotoxicity and highly active antiretroviral therapy: Mitigating action of Momordica charantia

Ugochukwu Offor1, Edwin Coleridge Naidu1, Oluwatosin Olalekan Ogedengbe1,2

  • 1Department of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, South Africa.

Toxicology Reports
|January 11, 2019
PubMed

Keywords:
6-HD, 6-hydroxydopamineAIDS, acquired immune deficiency syndromeALB, albuminANOVA, analysis of varianceAREC, animal research ethics committeeBGL, blood glucose levelsBRU, Biomedical Resource UnitBUN, blood urea nitrogenBW, body weightCAT, catalaseDETAPAC, diethylenetriamine – penta acetic acidDNA, deoxyribonucleic acidDTNB, 5, 5'-dithiobis-(2-nitrobenzoic acid)GSH, reduced glutathioneH and E, haematoxylin and eosinHAARTHAART, highly active antiretroviral therapyHIV, human immunodeficiency virusHistopathologyKW, kidney weightKWBR, kidney weight body ratioKidneyLPO, lipid peroxidationM. charantia, Momordica charantiaMDA, malondialdehydeMT, Masson’s TrichomeMomordica charantiaNRTIs, nucleoside reverse transcriptase inhibitorsNephrotoxicityPAS, Periodic Acid SchiffPBS, phosphate buffer solutionPLWHA, people living with HIV and AIDSROS, reactive oxygen speciesSCr, serum creatinineSD, standard deviationSDS, sodium dodecyl sulfateSOD, superoxide dismutaseSprague-Dawley ratsTBARS, thiobarbituric acid reactive substancesTCA, trichloroacetic acidUKZN, University of KwaZulu Natalrpm, revolutions per minute

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