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Related Concept Videos

Frequency-dependent Selection01:21

Frequency-dependent Selection

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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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[VEXAS syndrome].

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The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics
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The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics

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[Vasculitis mimics].

I Kötter1, E Reinhold-Keller2

  • 1Rheumatologie, Klinische Immunologie, Nephrologie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland. ina.koetter@asklepios.com.

Zeitschrift Fur Rheumatologie
|January 11, 2019
PubMed
Summary
This summary is machine-generated.

Differentiating vasculitis mimics from primary and secondary vasculitides is crucial. These mimics, caused by genetic mutations, infections, or lymphomas, present similar symptoms to classical vasculitic disorders.

Keywords:
B-cell lymphomaBehcet syndromeChapel Hill nomenclatureGranulomatosis with polyangiitisLack of response to treatment

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Area of Science:

  • Rheumatology
  • Internal Medicine
  • Pathology

Background:

  • Vasculitis, inflammation of blood vessels, requires careful diagnosis to distinguish from conditions with similar clinical presentations.
  • The Chapel Hill nomenclature provides a framework for classifying primary and secondary vasculitides.
  • Clinical symptoms of vasculitis mimics can resemble those of small, medium, and large vessel vasculitis.

Purpose of the Study:

  • To summarize and differentiate various conditions that mimic vasculitis.
  • To highlight the importance of distinguishing vasculitis mimics from true vasculitic disorders.

Main Methods:

  • Review of literature on vasculitis mimics.
  • Analysis of clinical symptomatology and pathogenetic causes.

Main Results:

  • Vasculitis mimics present with clinical features similar to classical vasculitic disorders.
  • Identified causes of vasculitis mimics include genetic mutations, embolization syndromes, infections, substance abuse, and B-cell lymphomas.

Conclusions:

  • Accurate differentiation of vasculitis mimics is essential for appropriate patient management.
  • Understanding the diverse etiologies of vasculitis mimics aids in diagnosis and treatment strategies.