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Related Experiment Video

Updated: Jan 30, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
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Correlation Between Clinical Signs and High-resolution Manometry Data in Children.

Marine Juzaud1, Marie-Dominique Lamblin2,3, Alexandre Fabre1,4

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Summary

Weight loss is a strong predictor of abnormal esophageal motility disorder results, as confirmed by high-resolution manometry (HRM). This study evaluated clinical signs to improve diagnosis of these conditions.

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Area of Science:

  • Gastroenterology
  • Esophageal Physiology
  • Diagnostic Accuracy

Background:

  • High-resolution manometry (HRM) is the standard for diagnosing esophageal motility disorders.
  • Clinical signs for these disorders are often nonspecific, complicating correlation with HRM data.

Purpose of the Study:

  • To assess the positive predictive value (PPV) and negative predictive value (NPV) of clinical signs in diagnosing esophageal motility disorders.
  • To determine the sensitivity and specificity of these signs.

Main Methods:

  • A bicentric retrospective cohort study analyzed 271 HRM data from May 2012 to May 2016.
  • Symptoms evaluated included weight loss, dysphagia, GERD, and respiratory issues, with HRM data analyzed using the Chicago Classification (3.0).

Main Results:

  • 90.4% of HRM analyses revealed abnormal results.
  • Ineffective esophageal motility was the most common disorder (38%).
  • Weight loss showed a significant association (P=.003) with abnormal HRM, boasting a 96% PPV.

Conclusions:

  • Weight loss emerged as a significant predictive clinical sign for abnormal HRM results.
  • HRM was well-tolerated in pediatric patients.
  • Ineffective esophageal motility is the most frequent disorder in this cohort, consistent with adult studies.