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[Hemodynamic changes and left ventricular function in patients with hypertension during an acute trial of urapidil]
Insights
Intravenous Urapidil rapidly lowers blood pressure and peripheral resistance in hypertensive patients. This medication improves left ventricular function by increasing shortening fractions and ejection fraction.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Research
Background:
- Hypertension significantly impacts left ventricular function.
- Understanding hemodynamic changes is crucial for managing hypertensive emergencies and severe forms of the disease.
Purpose of the Study:
- To investigate the acute effects of intravenous Urapidil on left ventricular hemodynamics in hypertensive patients.
- To assess Urapidil's impact on cardiac function parameters.
Main Methods:
- Simultaneous M-type echocardiogram, apexcardiogram, and phonocardiogram recordings were used.
- Acute intravenous administration of Urapidil at 0.7 mg/kg body mass.
- Measurements included arterial pressure, peripheral vascular resistance, ventricular dimensions, and cardiac function indices.
Main Results:
- Urapidil caused a significant decrease in arterial pressure and peripheral vascular resistance.
- Left ventricular end-diastolic and end-systolic dimensions decreased.
- Fractional shortening, ejection fraction, and mean circumferential fiber shortening velocity increased significantly.
Conclusions:
- Intravenous Urapidil demonstrates rapid hypotensive action in hypertensive patients.
- Urapidil effectively improves left ventricular function in the acute setting.
Abstract:
The left ventricular hemodynamic changes were studied in 9 hypertensive patients (6 patients with hypertensive attack and 3 patients with a severe form of the disease) by simultaneous recordings of the M-type echocardiogram, apexcardiogram and phonocardiogram in an acute trial with Urapidil administered intravenously in a dose of 0,7 mg/kg body mass. The arterial pressure and the peripheral vascular resistance decrease. The stroke and the minute volume do not change. The heart rate increases. The telediastolic and telesystolic dimensions of the left ventricle decrease. The percentage amplitude of the aI-wave of the apexcardiogram also decreases. The fraction of the shortening of the left ventricular dimension increases with 23,0%, the ejection fraction increases with 13,5% and the average speed of the circumferential fibres shortening increases with 21,4%. Urapidil applied i.v. exerts a rapid hypotensive action and improves the left ventricular function.