[Liver function parameters and fibrinogen in intra-arterial and intravenous PGE1 infusion]

It has been claimed that PGE 1 pathologically alters liver function, the effect being less pronounced after intra-arterial administration. A retrospective data analysis of 4 different studies does not support this view. There was no effect on serum transaminases, fibrinogen or blood sedimentation rate. Furthermore, there was no difference between the i.a. and i.v. route of PGE 1 therapy under the investigated conditions. Thus, the claim that impaired liver function is less pronounced after i.a. PGE 1 administration is no longer valid.