TopoLink: evaluation of structural models using chemical crosslinking distance constraints

Allan J R Ferrari1, Milan A Clasen2, Louise Kurt2

  • 1Institute of Chemistry, University of Campinas, Campinas, SP, Brazil.

Abstract

Related Concept Videos

Distance Problem01:29

Distance Problem

When an object's velocity changes over time, the total distance traveled can be determined by summing small displacement intervals over short increments. This approach approximates the true distance through numerical summation and the use of integral calculus. An estimate of the total displacement can be obtained by measuring velocity at regular intervals and multiplying each value by the corresponding time step.If a runner accelerates over the first three seconds of a race, speed measurements...
66
Short-distance Transport of Resources02:12

Short-distance Transport of Resources

Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.
17.7K
Chemical Formulas02:52

Chemical Formulas

A chemical formula presents information about the proportions of atoms constituting a particular chemical compound or molecule, mainly using symbols of elements and numbers. At times other symbols, such as dashes, parentheses, brackets, commas, plus, and minus signs, are also used. A chemical formula can be one of three types – molecular, empirical, and structural.
61.2K
Constraints and Statical Determinacy01:26

Constraints and Statical Determinacy

In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
1.0K
The Distance Formula01:20

The Distance Formula

In geometry, measuring the direct distance between two points on a plane is essential in various practical and theoretical applications. Whether in navigation, engineering, or computer graphics, determining the shortest path between two locations involves using the distance formula. This formula is derived from the Pythagorean Theorem, which relates the lengths of the sides of a right triangle. On a coordinate plane, the horizontal and vertical distances between two points serve as the legs of...
646
Distance Corrections01:15

Distance Corrections

To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
288