Peripheral Neuropathy Research Registry: A prospective cohort

Area of Science:

• Neurology
• Clinical Research
• Biomarker Discovery

Background:

• Peripheral neuropathy (PN) encompasses diverse conditions, including idiopathic axonal PN, diabetic PN, HIV-associated PN, and chemotherapy-induced PN.
• Understanding the heterogeneity of PN is crucial for developing targeted therapies and effective symptom management.
• The Foundation for Peripheral Neuropathy (FPN) initiated the Peripheral Neuropathy Research Registry (PNRR) to address these needs.

Purpose of the Study:

• To establish a prospective, multi-center cohort of well-characterized PN patients.
• To facilitate research into the causes, phenotypes, and biomarkers of various PN types.
• To advance the development of disease-altering treatments and improve symptom relief for PN patients.

Main Methods:

• Prospective enrollment of patients with idiopathic axonal PN and comparison groups (diabetic, HIV-, chemotherapy-induced PN).
• Multi-center collaboration collecting detailed patient data and diverse phenotypes.
• Utilizing untargeted-omics methodologies for advanced data analysis.

Main Results:

• The PNRR has enrolled 1150 patients to date.
• Detailed study design, data collection methods, and initial patient characteristics are presented.
• Ongoing analyses are exploring complex datasets, including omics data.

Conclusions:

• The PNRR provides a valuable resource for PN research.
• The registry is poised to advance understanding of PN etiology and identify novel therapeutic targets.
• This initiative aims to significantly improve the lives of individuals affected by peripheral neuropathy.