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Updated: Jan 30, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
[Risk of treatment failure and therapeutic novelties in asthma]
Alice Horisberger1, Rima Mahdi Aljedani1, François Spertini1
1Service d'immunologie et allergie, Département de médecine interne, CHUV, 1001 Lausanne.
Abstract:
Asthma is a chronic disease that is still frequently poorly controlled, despite recent advances in understanding its pathophysiology. Poor compliance and ineffective inhalation technique remain the main causes of treatment failure. The comorbidities associated with asthma, such as obesity and chronic rhinosinusitis, are other elements to consider in the management of patients. Biological treatments targeting inflammation mediators show encouraging results in recurrent asthma exacerbations despite optimal management. However, their benefit remains limited to certain patients, thus requiring the study of predictive biomarkers to better delineate their indication.
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