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[Alcohol and endocrinologic homeostasis].

E Keck1, F L Degner, R Schlaghecke

  • 1Medizinische Klinik C und Poliklinik, Universität Düsseldorf.

Zeitschrift Fur Gastroenterologie
|October 1, 1988
PubMed
Summary

Chronic alcohol intake disrupts endocrine regulation via liver dysfunction, impacting hormones like testosterone, estradiol, and prolactin. This leads to various hormonal imbalances affecting multiple bodily systems.

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Area of Science:

  • Endocrinology
  • Hepatology
  • Toxicology

Context:

  • Chronic alcohol consumption significantly impacts liver function.
  • Alcohol-induced liver cirrhosis disrupts the normal regulation of endocrine systems.
  • Hormonal imbalances are a common consequence of long-term alcohol abuse.

Purpose:

  • To elucidate the multifaceted effects of chronic alcohol intake on the endocrine system.
  • To detail the specific hormonal alterations observed in patients with alcohol-induced liver cirrhosis.
  • To investigate the impact of alcohol on the gonadal, thyrotropic, corticotropic, calcitropic, and glucose-regulating axes.

Summary:

  • Alcohol intake impairs liver function, leading to hormonal dysregulation across multiple endocrine axes.
  • Patients with alcohol-induced liver cirrhosis exhibit low testosterone, elevated estradiol, altered thyroid hormones (low T3/T4, high rT3), elevated prolactin, STH, and free cortisol.
  • Disturbances also include impaired glucose tolerance, elevated insulin/glucagon, and calcitropic axis dysfunction causing bone disease.

Impact:

  • Highlights the systemic endocrine consequences of chronic alcohol abuse and liver disease.
  • Provides a comprehensive overview of hormonal changes associated with alcohol-induced liver cirrhosis.
  • Underscores the need for endocrine monitoring and management in patients with chronic alcoholism.

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