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A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Efficient Semi-Synthesis of Natural δ-( R)-Tocotrienols from a Renewable Vegetal Source
Alexia Ville1, Guillaume Viault1, Jean-Jacques Hélesbeux1
1SONAS, EA921, UNIV Angers , SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 bd Daviers , 49045 Angers Cedex 01, France.
Abstract:
Recent studies have highlighted the biological potential of tocotrienols, a vitamin E subfamily. The major natural sources of tocotrienols are complex mixtures requiring particularly challenging purification processes. The present study describes efficient semi-synthetic strategies toward relevant δ-( R)-tocotrienol derivatives, using as a starting material δ-( R)-garcinoic acid, the major vitamin E derivative isolated from Garcinia kola nuts, a renewable vegetal source.
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