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A comparison between continuous and batch processes to produce phosphatidylserine in the efficient and green
Binglin Li1, Jiao Wang1, Jing Li1
1School of Chemical Engineering, Northwest University, 710069, Xi'an, Shaanxi, China.
Biotechnology Progress
|January 11, 2019
Summary
This study introduces an eco-friendly method using modified silica as an artificial interface for enzymatic reactions. This approach enables efficient production of valuable compounds without toxic solvents, paving the way for green chemistry applications.
Area of Science:
- Biotechnology and Chemical Engineering
- Enzyme catalysis
- Green chemistry
Background:
- Phosphatidylcholine (PC) is a crucial phospholipid.
- Enzymatic modification of PC is important for various applications.
- Traditional methods often involve toxic solvents.
Purpose of the Study:
- To develop an efficient and environmentally friendly method for PC modification.
- To utilize an artificial interface for enzymatic transphosphatidylation.
- To explore batch and continuous production systems for phospholipase D (PLD) catalysis.
Main Methods:
- Aqueous-solid systems using Triton-X-100-modified silica as an artificial interface.
- Adsorption of PC onto silica in aqueous solutions.
- PLD-mediated transphosphatidylation of silica-adsorbed PC.
- Comparison of batch and continuous production technologies.
- Elution of products using coconut oil for capsule manufacturing.
Main Results:
- Silica-adsorbed PC was successfully used for PLD-catalyzed transphosphatidylation.
- Batch technology yielded the highest product amounts.
- Continuous production offered simpler operations and higher space-time yield.
- Toxic solvents were completely avoided throughout the process.
- Successful preparation of hard, soft, and microcapsules.
Conclusions:
- The developed aqueous-solid system provides an efficient and green route for PC modification.
- Both batch and continuous systems are viable, with distinct advantages for yield and operational simplicity.
- The method facilitates the production of encapsulated products without hazardous solvents.
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