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Short commentary on NDMA (N-nitrosodimethylamine) contamination of valsartan products
David J Snodin1, David P Elder2
1Xiphora Biopharma Consulting, Bristol, UK.
Abstract:
A range of generic valsartan products have been found to be contaminated with nitrosamines (principally N-nitrosodimethylamine; NDMA). We present information and discuss various elements of this phenomenon including: actions taken by regulatory agencies, source of the nitrosamine impurities, range of possible risk assessments based mainly on ICH M7 criteria, epidemiological assessment and analytical aspects.
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