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HBV Genotype-Specific Levels of Hepatitis B Surface Antigen Improve HBV Phenotype Definition
Willem P Brouwer1, Qian Zhao2, Bettina E Hansen3
1Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Canada; Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Abstract:
Controversies exist regarding the classification of the different clinical phases of chronic hepatitis B (CHB) because hepatitis B virus (HBV) DNA and alanine aminotransferase levels fluctuate over time.1,2 To improve the distinction of clinical phases and the associated spectrum of clinical outcome,3,4 hepatitis B surface antigen (HBsAg) levels may be of help.5-7 We hypothesize that HBV genotype specific HBsAg levels are needed for the identification of different clinical HBV disease phases.7.
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