Related Experiment Video
Updated: Jan 30, 2026

Peering into the Dynamics of Social Interactions: Measuring Play Fighting in Rats
Published on: January 18, 2013
When Calcium Gets Tough, the Tough Cardiologist Starts to Play …
Eliezer Joseph Tassone1, Cesare Tripolino2, Gaetano Morabito2
1Department of Cardiac Surgery, Cardiology Unit, Sant'Anna Hospital, Catanzaro, Italy, eliezerjoseph.tassone@gmail.com.
Insights
Coronary calcification poses challenges in stenting. Lithotripsy-enhanced disruption using the Shockwave Coronary Lithoplasty System offers a safer alternative for treating calcified restenosis within stents.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Devices
Background:
- Coronary calcification presents significant challenges for interventional cardiologists, often leading to incomplete stent expansion and stent failure.
- Traditional treatments like rotational atherectomy carry increased procedural risks.
- Novel techniques are crucial for managing complex calcified coronary lesions.
Observation:
- A 60-year-old male experienced restenosis within a previously stented ramus intermedius due to severe calcification.
- Initial treatment with rotational atherectomy was followed by persistent symptoms.
- The patient subsequently underwent lithotripsy-enhanced disruption of calcium using the Shockwave Coronary Lithoplasty System.
Findings:
- The Shockwave Coronary Lithoplasty System successfully treated calcified restenosis within the existing stent.
- This technique utilizes sonic waves to safely fracture calcified lesions.
- This represents the first reported case of using this system for in-stent calcified restenosis.
Implications:
- Lithotripsy-enhanced disruption offers a potentially safer and simpler approach for treating complex calcified coronary lesions, including in-stent restenosis.
- This technology may expand treatment options for patients with challenging coronary anatomy.
- Further research is warranted to establish the long-term efficacy and safety of this innovative technique.
Abstract:
Coronary calcification is a hard challenge for the interventional cardiologist, as it is associated with incomplete stent expansion and frequently stent failure. In recent years, innovative techniques, such as rotational atherectomy, have been developed to treat coronary calcification. However, these are burdened with an increased procedural risk. We report the case of a 60-year-old Caucasian man treated 1 month before at another center with primary coronary angioplasty and stenting of the ramus intermedius for coronary syndrome. Coronary angiography showed a critical stenosis of the left main coronary artery as well as critical calcified stenosis of the left anterior descending artery and the diagonal branch. Coronary calcification was treated with rotational atherectomy that preceded the angioplasty and stenting. Because of persistence of the symptomatology, coronary angiography was repeated 1 month later and showed a critical calcified restenosis of the ramus intermedius at the site of the previous stenting. Considering the high risk of traditional atherectomy, we performed lithotripsy-enhanced disruption of calcium beyond the stents with the Shockwave Coronary Lithoplasty System. The Shockwave Coronary Lithoplasty System has been introduced recently in order to treat calcified coronary lesions with greater safety. The procedure allows most calcified coronary lesions to be treated with simplicity and safety. This system employs sound waves, similar to those used for treating kidney stones, to crush the calcified lesions. We present the first case described to date in whom this technique was successfully used to treat calcified restenosis in a previous stent.
Related Concept Videos
Toughness and Hardness of Aggregate
Social Foundations of Self I: Play and Game
The Stanford Prison Experiment
The Extracellular Matrix
Skeleton and Calcium Homeostasis
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily...

