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Updated: Jan 30, 2026

Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
Published on: February 11, 2021
[Analysis of tracheal morphology by spiral CT in 126 cleft palate children]
1Department of General Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Insights
Cleft palate children with airway stenosis have narrower upper airways, particularly in the subglottic and cricoid areas. Surgical intubation using a visible laryngoscope proved safe and effective for these patients.
Area of Science:
- Pediatric Surgery
- Otolaryngology
- Anesthesiology
Background:
- Cleft palate is a congenital condition that can lead to complex airway challenges.
- Airway stenosis in cleft palate patients poses significant risks during surgical procedures, especially intubation.
- Understanding the specific anatomical characteristics of the upper airway in these children is crucial for surgical planning.
Purpose of the Study:
- To analyze the upper airway shape characteristics in cleft palate children with and without airway stenosis.
- To evaluate the surgical safety and efficacy of endotracheal intubation in cleft palate children with airway stenosis.
- To compare clinical data between cleft palate children with and without airway stenosis.
Main Methods:
- Retrospective analysis of 126 cleft palate children (2015-2017).
- Categorization into airway-stenosis (65) and non-airway-stenosis (61) groups based on spiral CT scans.
- Comparison of upper airway measurements, intubation success rates, operation times, and hospital stays; use of visible laryngoscope for suspected difficult intubations.
Main Results:
- The upper airway in both groups exhibited an elliptical shape, narrow transversely and wide anteroposteriorly, in the subglottic and cricoid areas.
- The airway-stenosis group showed significantly narrower anteroposterior dimensions in the subglottis and narrower transverse and anteroposterior dimensions in the cricoid area compared to the non-stenosis group.
- All patients had normal postoperative oxygen saturation, successful ventilator weaning, and no significant differences in operation time or hospital stay between groups.
Conclusions:
- Cleft palate children commonly present with elliptical upper airways (subglottic and cricoid areas), characterized by narrow transverse and wide anteroposterior dimensions.
- Surgical intubation in cleft palate children with airway stenosis can be performed safely and smoothly using a portable visible laryngoscope.
- The anatomical findings support tailored intubation strategies for managing airway stenosis in this patient population.
Abstract:
Objective: To discuss the surgical safeness of the cleft palate children with airway stenosis by means of analyzing characteristics of the shape of the upper airway and comparing clinical data of cleft palate children with airway stenosis and non-airway stenosis. Methods: Tracing back from Apirl 2015 to Apirl 2017, 126 cleft palate children treated in Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, were included (46 male and 80 female, age of 7 to 74 months, median age 18 months). According to the spiral CT scan of neck, patients were categorized to airway-stenosis group (65 patients) and non-airway-stenosis group (61 patients). For airway-stenosis group, suspected difficult intubation plan is applied, guiding endotracheal intubation via visible laryngoscope. For non-airway-stenosis group, ordinary plan of endotracheal intubation is applied. Study the statistics of both groups in the measurement of the upper airway, the success rate of tracheal intubation, operation time, hospital day. Results: Based on anatomical location of the airway stenosis, cleft palate children were divided into: nasopharynx, 5 cases; laryngel, 55 cases; initiation part of trachea to arch of aorta, 2 cases; arch of aorta to bronchial bifurcation, 3 cases. Regardless of airway stenosis, the upper airway of cleft palate children in the subglottic area and the cricoid area was elliptical, with the transverse dimension narrow and the anteroposterior dimension wide. Comparing to non-airway-stenosis group, the airway in airway-stenosis group remained narrower in the anteroposterior dimension in the subglottis area [(7.69±1.76) mm]; also remained narrower in the transverse dimension [(5.96±1.27) mm] and the anteroposterior dimension [(8.16±1.31) mm] in the cricoid area (P<0.05). Pre-and post-operative monitor blood oxygen saturation of all patients were normal. Ventilator weaning of all patients was successful. There were no statistical significance in operation time and hospital day between airway-stenosis group and non-airway-stenosis group (P>0.05). Conclusions: The upper airway of the subglottic area and the cricoid area in cleft palate children are elliptical, with the transverse dimension narrow and the anteroposterior dimension wide. Cleft palate children with airway stenosis underwent surgery smoothly by using a portable visible laryngoscope.
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