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[Initial experiences in the use of pulsatile Gn-RH administration for ovulation induction]
M Nehmzow1, M Rüting, G Göretzlehner
1Klinik und Poliklinik für Gynäkologie und Geburtshilfe, Bereichs Medizin der Ernst-Moritz-Arndt Universität.
Zentralblatt Fur Gynakologie
|January 1, 1988
Summary
Pulsatile administration of gonadotropin-releasing hormone (Gn-RH) successfully induced ovulation in 9 patients. This treatment led to pregnancies in 5 of the women, demonstrating its effectiveness for fertility induction.
Area of Science:
- Reproductive Endocrinology
- Hormone Therapy
- Infertility Treatment
Context:
- Pulsatile gonadotropin-releasing hormone (Gn-RH) therapy is a method for ovulation induction.
- This study evaluated two specific Gn-RH delivery systems: the Zyklomat minipump (Ferring) and a Gn-RH pump (ZID Karlsburg).
Purpose:
- To assess the efficacy of pulsatile Gn-RH administration in inducing ovulation and subsequent pregnancy.
- To evaluate the clinical application of two different Gn-RH delivery devices.
Summary:
- Thirteen treatment cycles involving pulsatile Gn-RH administration were conducted in 9 patients.
- Dosages ranged from 2.5 to 20 micrograms per pulse over 10 to 18 days.
- Ovulation was achieved in all 9 patients, and 5 patients achieved pregnancy.
Impact:
- Pulsatile Gn-RH therapy is an effective treatment for inducing ovulation in infertile patients.
- The study highlights the successful application of Gn-RH pumps in achieving pregnancies.
- This approach offers a viable option for assisted reproductive technology.